Thursday, March 6, 2014

Toxic Granulated Neutrophils

Toxic Granulated Neutrophils

Background Information of Toxic Granulated Neutrophils

Granules in normal segmented neutrophils in healthy humans are relatively small and not conspicuous. However, in patients with severe infection (sepsis), the granules are large and stain intensely. Hence presence of numerous such cells on a peripheral blood film is suggestive of an inflammatory process. Unfortunately, this is not case-specific as normal pregnancy can also lead to an increase in toxic granulated neutrophils.

Cellular Description

The size of toxic-granulated neutrophils are similar as their matured segmented neutrophils counterparts with their segmented nucleus stained dark purple. The major difference between the 2 is that the toxic-granulated neutrophils contains numerous dark purple precipitates/inclusions (AKA Dohle Bodies)

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