Background Information of Vacuolated Neutrophils
The presence of vacuolated polymorphonuclear neutrophils in blood smears of patients suffering from infection appears to be associated with massive bacterial growth and to constitute a very early symptom of rapidly life-threatening septicaemia. The presence of the vacuoles are indicative of increased spontaneous phagocytic activity of the neutrophils in response to septicemia. When these cells persist for more than 36 hours, the disease may be considered as beyond control.
The size of vacuolated neutrophils are similar as their matured segmented neutrophils counterparts with their segmented nucleus stained dark purple. The major difference between the 2 is that the vacuolated neutrophils contains few to multiple white spaces (vacuoles) within their pink cytoplasm