Wednesday, March 5, 2014

Band-Form Neutrophils

Band-Form Neutrophils

Background Information of Band-From Neutrophils

This is the last stage where all neutrophils will cross before leading to their transformation into matured polymorphonucleus neutrophils  (AKA segmented neutrophils)

Cellular Description

The size of band forms are similar as their matured segmented neutrophils counterparts and their cytoplasm contains lightly stained purple granules too. The major difference between the 2 is that the band forms consist of a nucleus that lacks distinct segments, which usually appear in a curved C-shaped or S shaped. Occasionally some will have a rod-shaped nucleus.

Normal Reference Range

In adults: 3% to 5% of WBCs or up to 0.7 x 10^9/L

Clinical Significance

An excess of band-formed neutrophils indicates bandemia. Bandemia is a clinical condition where the bone marrow releases an excess of band-formed neutrophils which usually signify an on-going infection (or sepsis) or inflammation. The increased proportion of these cells is often referred as "left-shift" but is not specifically related to infection as other marrow "stressors" may produce synonymous effects too.

It can also play a role in the maintenance of appendicitis.

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