Wednesday, March 5, 2014

Polymorphonuclear (Segmented) Neutrophils

Polymorphonuclear (Segmented) Neutrophils

Background Introduction

Considered as the first responder cells to combat against pathogens that breach the non-specific first line of defence, neutrophils are professional phagocytic cells that derives in the bone marrow. Their primary functions revolve phagocytising microbes and exterminating them. They are rich in granules that contain bactericidal enzymes such as cathepsins, proteinase-3, elastase, azurocidin and lysozymes. Concomitantly, neutrophils also possess defensins that permeabilize bacterial membranes.

Cellular Description 

These normal polymorphonuclear neutrophils have nucleus that are segmented into lobules by filaments. There are usually 3 to 4 lobules in each neutrophils. Approximately twice the size of a RBC. Their cytoplasm should contain numerous lightly stained purple granules.

Types of Mature Neutrophils
  • Band-Forms
  • Agranular/Hypogranular 
  • Hyper-segmented 
  • Toxic granulated
  • Vacuolated 
  • Pelger-Huet anomaly

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