Polymorphonuclear (Segmented) Neutrophils
Background Introduction
Considered
as the first responder cells to combat against pathogens that breach the
non-specific first line of defence, neutrophils are professional
phagocytic cells that derives in the
bone marrow. Their
primary functions revolve phagocytising microbes and exterminating them. They are rich in granules that contain
bactericidal enzymes such as cathepsins, proteinase-3, elastase, azurocidin and lysozymes. Concomitantly, neutrophils also possess defensins that
permeabilize bacterial membranes.
Cellular Description
These normal polymorphonuclear neutrophils have nucleus that are segmented into lobules by filaments. There are usually 3 to 4 lobules in each neutrophils. Approximately twice the size of a RBC. Their cytoplasm should contain numerous lightly stained purple granules.
Types of Mature Neutrophils
- Band-Forms
- Agranular/Hypogranular
- Hyper-segmented
- Toxic granulated
- Vacuolated
- Pelger-Huet anomaly
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